1)Designs and implements biochemical and cellular assays to guide the target validation primarily in the areas of oncology, immunology and neurosciences;
2)Leads the design and implementation of screening strategies for Hit Identification through either High Throughput Screening or other technologies;
3)Provides leadership in developing innovative approaches to screening and hit triage;
4)Ensures hits are pharmacologically relevant by applying necessary validation assays;
5)Analyzes validation and screening data including presentation at program team meetings;
6)Works with other leaders in non-clinical R&D to design mechanisms of action studies for drug candidates;
7)Responsible for grow internal talents and capabilities through recruiting and mentoring
1)PhD in biochemistry, biophysics, cell biology, pharmacology or related areas with a minimal of 8 years of industry experience;
2)Strong expertise in in vitro profiling and pharmacology using biochemical, biophysical, and cell based methods in at least one of the three therapeutic areas: oncology, immunology and neurosciences.;
3)Record of success in assay development for Hit Identification using biochemical and cellular methods;
4)Demonstrated experience and expertise with Hit triage;
5)In-depth knowledge of entire drug discovery process;
6)Good communication skills and experience of working external collaborators.
一家极具创新力的大型制药集团,产品覆盖:抗肿瘤,风湿免疫,中枢神经,心血管,抗感染等领域;目前在研项目30多个近10个创新药项目。该集团研发中心管理层拥有多年巨头管理工作经验。