1）Manage scientific staff and external resources (academic and CROs) to deliver quality data in an efficient manner to support biological drug discovery programs across a variety of target and disease areas.
2）Oversee development and use of oncology/immune-oncology therapeutic models (e.g. humanized mouse models, syngeneic tumor model, PDX, CDX, GEMMs, and orthotopic models.), some of the immunology models (e.g. CIA/AIA, psoriasis, EAE, IBD etc.), or some infectious disease models.
3）Chair a multi-disciplinary in vivo committee that will supervise the daily operation of the animal facility to remain compliant with IACUC and AALAC regulations, evaluate and approve all in vivo study design and ensure appropriate resources for executing these studies.
4. Identify and implement best-fit strategy to prioritize studies to provide preclinical data package for clinical development of key assets.
5）Manage and supervise study planning, protocol design, study implementation and result publishing.
6）Present project update and science to senior management.
1）PhD in immunology, pharmacology or other life science-related disciplines with a minimum 5 years of oversea postdoctoral experiences and good publication record. Experience in oncology and running in vivo studies for immune-oncology drug candidates is preferred. Experience working with therapeutic monoclonal antibody is a plus.
2）Strong understanding of key components and process of drug discovery, applied pharmacology, and drug development.
3）Strong working knowledge of oncology/immunology disease processes, disease models, and current clinical treatments.
4）Experience and working knowledge including but not limited to genetic engineering, stable gene expression/knockdown platforms, cell and tumor biology, molecular profiling methodologies, histology/immunohistochemistry, FACS, in vivo imaging, etc.
5）Proven track record to manage an in vivo pharmacology group in a matrixed environment.
6）Strong communication skills and ability to work effectively across multiple multidisciplinary teams and across sites.
7）Familiarity with the regulatory requirements to run an in vivo facility.